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LRRK2 and ubiquitination: implications for kinase inhibitor therapy

Pathogenic mutations and risk variants in LRRK2 (leucine-rich repeat kinase 2) represent the most common genetic cause of familial and sporadic PD (Parkinson's disease). LRRK2 protein is widely expressed throughout the brain and the periphery. Structurally, LRRK2 contains several functional dom...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochem J
Prif Awdur: Melrose, Heather L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Portland Press Ltd. 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613699/
https://ncbi.nlm.nih.gov/pubmed/26341487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20150785
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