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Structure-based design and functional studies of novel noroviral 3C protease chimaeras offer insights into substrate specificity
The norovirus NS6 protease is a key target for anti-viral drug development. Noroviruses encode a 2200 amino acid polyprotein which is cleaved by this critical protease at five defined boundary substrates into six mature non-structural (NS) proteins. Studies of the human norovirus (HNV) NS6 protease,...
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| Publicado no: | Biochem J |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4613530/ https://ncbi.nlm.nih.gov/pubmed/25275273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140959 |
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