Tim-3 blocking rescue macrophage and T cell function against Mycobacterium tuberculosis infection in HIV+ patients

INTRODUCTION: T cell immunoglobulin and mucin domain (Tim) 3 and programmed death 1 (PD-1) are co-inhibitory receptors involved in the so-called T cell exhaustion, and in vivo blockade of these molecules restores T cell dysfunction. High expression of Tim-3 and PD-1 is induced after chronic antigen-...

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Bibliografske podrobnosti
izdano v:J Int AIDS Soc
Main Authors: Sada-Ovalle, Isabel, Ocaña-Guzman, Ranferi, Pérez-Patrigeón, Santiago, Chávez-Galán, Leslie, Sierra-Madero, Juan, Torre-Bouscoulet, Luis, Addo, Marylyn M.
Format: Artigo
Jezik:Inglês
Izdano: International AIDS Society 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612469/
https://ncbi.nlm.nih.gov/pubmed/26486200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7448/IAS.18.1.20078
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