Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis

Cohesin complex members have recently been identified as putative tumor suppressors in hematologic and epithelial malignancies. The cohesin complex guides chromosome segregation; however, cohesin mutant leukemias do not show genomic instability. We hypothesized that reduced cohesin function alters c...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Viny, Aaron D., Ott, Christopher J., Spitzer, Barbara, Rivas, Martin, Meydan, Cem, Papalexi, Efthymia, Yelin, Dana, Shank, Kaitlyn, Reyes, Jaime, Chiu, April, Romin, Yevgeniy, Boyko, Vitaly, Thota, Swapna, Maciejewski, Jaroslaw P., Melnick, Ari, Bradner, James E., Levine, Ross L.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2015
Fag:
Brief Definitive Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612085/
https://ncbi.nlm.nih.gov/pubmed/26438361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151317
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