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Combining silver- and organocatalysis: an enantioselective sequential catalytic approach towards pyrano-annulated pyrazoles

A one-pot asymmetric Michael addition/hydroalkoxylation sequence, catalyzed by a sequential catalytic system consisting of a squaramide and a silver salt, provides a new series of chiral pyrano-annulated pyrazole derivatives in excellent yields (up to 95%) and high enantioselectivities (up to 97% ee...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Chem Commun (Camb)
Hauptverfasser: Hack, Daniel, Chauhan, Pankaj, Deckers, Kristina, Mizutani, Yusuke, Raabe, Gerhard, Enders, Dieter
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611987/
https://ncbi.nlm.nih.gov/pubmed/25564304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cc09495f
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