Premature termination codons are recognized in the nucleus in a reading-frame-dependent manner

mRNAs containing premature termination codons (PTCs) are known to be degraded via nonsense-mediated mRNA decay (NMD). Unexpectedly, we found that mRNAs containing any type of PTCs (UAA, UAG, and UGA) are detained in the nucleus, whereas their wild-type counterparts are rapidly exported. This retenti...

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Bibliografski detalji
Izdano u:Cell Discov
Glavni autori: Shi, Min, Zhang, Heng, Wang, Lantian, Zhu, Changlan, Sheng, Ke, Du, Yanhua, Wang, Ke, Dias, Anusha, Chen, She, Whitman, Malcolm, Wang, Enduo, Reed, Robin, Cheng, Hong
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4610414/
https://ncbi.nlm.nih.gov/pubmed/26491543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2015.1
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