Premature termination codons are recognized in the nucleus in a reading-frame-dependent manner

mRNAs containing premature termination codons (PTCs) are known to be degraded via nonsense-mediated mRNA decay (NMD). Unexpectedly, we found that mRNAs containing any type of PTCs (UAA, UAG, and UGA) are detained in the nucleus, whereas their wild-type counterparts are rapidly exported. This retenti...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: Shi, Min, Zhang, Heng, Wang, Lantian, Zhu, Changlan, Sheng, Ke, Du, Yanhua, Wang, Ke, Dias, Anusha, Chen, She, Whitman, Malcolm, Wang, Enduo, Reed, Robin, Cheng, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4610414/
https://ncbi.nlm.nih.gov/pubmed/26491543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2015.1
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados