EF24 Induces G(2)/M Arrest and Apoptosis in Cisplatin-resistant Human Ovarian Cancer Cells by Increasing PTEN Expression

We report that EF24, a synthetic compound 3,5-bis(2-flurobenzylidene)piperidin-4-one, greatly inhibits cisplatin-resistant (CR) human ovarian cancer cell proliferation. The inhibitory effect of EF24 on cell proliferation is associated with G(2)/M phase cell cycle arrest and increased G(2)/M checkpoi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Selvendiran, Karuppaiyah, Tong, Liyue, Vishwanath, Shilpa, Bratasz, Anna, Trigg, Nancy J., Kutala, Vijay K., Hideg, Kalman, Kuppusamy, Periannan
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4610350/
https://ncbi.nlm.nih.gov/pubmed/17684018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M703796200
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