HIV-1 Tat membrane interaction probed using X-ray and neutron scattering, CD spectroscopy and MD simulations

We report the effect on lipid bilayers of the Tat peptide Y(47)GRKKRRQRRR(57) from the HIV-1 virus transactivator of transcription (Tat) protein. Synergistic use of low-angle X-ray scattering (LAXS) and atomistic molecular dynamics simulations (MD) indicate Tat peptide binding to neutral dioleoylpho...

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Bibliografske podrobnosti
izdano v:Biochim Biophys Acta
Main Authors: Akabori, Kiyotaka, Huang, Kun, Treece, Bradley W., Jablin, Michael S., Maranville, Brian, Woll, Arthur, Nagle, John F., Garcia, Angel E., Tristram-Nagle, Stephanie
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4610132/
https://ncbi.nlm.nih.gov/pubmed/25148702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2014.08.014
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