Identification of bromodomain-containing protein 4 (BRD4) as a novel marker and epigenetic target in mast cell leukemia

Advanced systemic mastocytosis (SM) is a life-threatening neoplasm characterized by uncontrolled growth and accumulation of neoplastic mast cells (MCs) in various organs and a poor survival. So far, no curative treatment concept has been developed for these patients. We identified the epigenetic rea...

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Veröffentlicht in:Leukemia
Hauptverfasser: Wedeh, Ghaith, Cerny-Reiterer, Sabine, Eisenwort, Gregor, Herrmann, Harald, Blatt, Katharina, Hadzijusufovic, Emir, Sadovnik, Irina, Müllauer, Leonhard, Schwaab, Juliana, Hoffmann, Thomas, Bradner, James E., Radia, Deepti, Sperr, Wolfgang R., Hoermann, Gregor, Reiter, Andreas, Horny, Hans-Peter, Zuber, Johannes, Arock, Michel, Valent, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4610040/
https://ncbi.nlm.nih.gov/pubmed/26055303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.138
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