Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML)

Acute myeloid leukemia (AML) is a life-threatening stem cell disease characterized by uncontrolled proliferation and accumulation of myeloblasts. Using an advanced RNAi screen-approach in an AML mouse model we have recently identified the epigenetic ‘reader’ BRD4 as a promising target in AML. In the...

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Autors principals: Herrmann, Harald, Blatt, Katharina, Shi, Junwei, Gleixner, Karoline V., Cerny-Reiterer, Sabine, Müllauer, Leonhard, Vakoc, Christopher R., Sperr, Wolfgang R., Horny, Hans-Peter, Bradner, James E., Zuber, Johannes, Valent, Peter
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2012
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681497/
https://ncbi.nlm.nih.gov/pubmed/23249862
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