“Store-operated” cAMP signaling contributes to Ca(2+)-activated Cl(−) secretion in T84 colonic cells

Apical cAMP-dependent CFTR Cl(−) channels are essential for efficient vectorial movement of ions and fluid into the lumen of the colon. It is well known that Ca(2+)-mobilizing agonists also stimulate colonic anion secretion. However, CFTR is apparently not activated directly by Ca(2+), and the exist...

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Udgivet i:Am J Physiol Gastrointest Liver Physiol
Main Authors: Nichols, Jonathan M., Maiellaro, Isabella, Abi-Jaoude, Joanne, Curci, Silvana, Hofer, Aldebaran M.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2015
Fag:
Hormones, Neurotransmitters, Growth Factors, Receptors, and Signaling
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609931/
https://ncbi.nlm.nih.gov/pubmed/26316590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00214.2015
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