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Human anti-α3(IV)NC1 antibody drug conjugates target glomeruli to resolve nephritis
Current therapies to limit kidney disease progression lack specificity and often have systemic toxicity. To approach this problem, we postulated that a human monoclonal antibody (F1.1), directed against the noncollagenous-1 domain (NC1) of α3(IV) collagen that localizes in glomeruli, could serve as...
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| izdano v: | Am J Physiol Renal Physiol |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Physiological Society
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4609920/ https://ncbi.nlm.nih.gov/pubmed/26290372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00289.2015 |
| Oznake: |
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