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Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.

Adaptive responses to hypoxia occur in many biological systems. A well-characterized example is the hypoxic induction of the synthesis of erythropoietin, a hormone which regulates erythropoiesis and hence blood oxygen content. The restricted expression of the erythropoietin gene in subsets of cells...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Maxwell, P H, Pugh, C W, Ratcliffe, P J
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 1993
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Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46099/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8460154/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.6.2423
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