CB1R antagonist increases hepatic insulin clearance in fat-fed dogs likely via upregulation of liver adiponectin receptors

The improvement of hepatic insulin sensitivity by the cannabinoid receptor 1 (CB1R) antagonist rimonabant (RIM) has been recently been reported to be due to upregulation of adiponectin. Several studies demonstrated that improvement in insulin clearance accompanies the enhancement of hepatic insulin...

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Veröffentlicht in:Am J Physiol Endocrinol Metab
Hauptverfasser: Kabir, Morvarid, Iyer, Malini S., Richey, Joyce M., Woolcott, Orison O., Asare Bediako, Isaac, Wu, Qiang, Kim, Stella P., Stefanovski, Darko, Kolka, Cathryn M., Hsu, Isabel R., Catalano, Karyn J., Chiu, Jenny D., Ionut, Viorica, Bergman, Richard N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2015
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609878/
https://ncbi.nlm.nih.gov/pubmed/26306598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00196.2015
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