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Lung Epithelial TRPA1 Transduces the Extracellular ROS into Transcriptional Regulation of Lung Inflammation Induced by Cigarette Smoke: The Role of Influxed Ca(2+)

The mechanism underlying the inflammatory role of TRPA1 in lung epithelial cells (LECs) remains unclear. Here, we show that cigarette smoke extract (CSE) sequentially induced several events in LECs. The Ca(2+) influx was prevented by decreasing extracellular reactive oxygen species (ROS) with the sc...

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Dades bibliogràfiques
Publicat a:Mediators Inflamm
Autors principals: Lin, An-Hsuan, Liu, Meng-Han, Ko, Hsin-Kuo, Perng, Diahn-Warng, Lee, Tzong-Shyuan, Kou, Yu Ru
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609484/
https://ncbi.nlm.nih.gov/pubmed/26504357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/148367
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