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Lung Epithelial TRPA1 Transduces the Extracellular ROS into Transcriptional Regulation of Lung Inflammation Induced by Cigarette Smoke: The Role of Influxed Ca(2+)

The mechanism underlying the inflammatory role of TRPA1 in lung epithelial cells (LECs) remains unclear. Here, we show that cigarette smoke extract (CSE) sequentially induced several events in LECs. The Ca(2+) influx was prevented by decreasing extracellular reactive oxygen species (ROS) with the sc...

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Detalhes bibliográficos
Publicado no:Mediators Inflamm
Main Authors: Lin, An-Hsuan, Liu, Meng-Han, Ko, Hsin-Kuo, Perng, Diahn-Warng, Lee, Tzong-Shyuan, Kou, Yu Ru
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609484/
https://ncbi.nlm.nih.gov/pubmed/26504357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/148367
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