Combining miR10b-targeted nanotherapy with low-dose doxorubicin elicits durable regressions of metastatic breast cancer

The therapeutic promise of microRNA in cancer has yet to be realized. In this study, we identified and therapeutically exploited a new role for miR-10b at the metastatic site, which links its overexpression to tumor cell viability and proliferation. In the protocol developed, we combined a miR-10b-i...

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Gepubliceerd in:Cancer Res
Hoofdauteurs: Yoo, Byunghee, Kavishwar, Amol, Ross, Alana, Wang, Ping, Tabassum, Doris P., Polyak, Kornelia, Barteneva, Natalia, Petkova, Victoria, Pantazopoulos, Pamela, Tena, Aseda, Moore, Anna, Medarova, Zdravka
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609288/
https://ncbi.nlm.nih.gov/pubmed/26359455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0888
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