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Therapy targeted to the metastatic niche is effective in a model of stage IV breast cancer

Treatment of stage IV metastatic breast cancer patients is limited to palliative options and represents an unmet clinical need. Here, we demonstrate that pharmacological inhibition of miRNA-10b - a master regulator of metastatic cell viability – leads to elimination of distant metastases in a mouse...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Yoo, Byunghee, Kavishwar, Amol, Wang, Ping, Ross, Alana, Pantazopoulos, Pamela, Dudley, Michael, Moore, Anna, Medarova, Zdravka
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359550/
https://ncbi.nlm.nih.gov/pubmed/28322342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45060
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