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Therapy targeted to the metastatic niche is effective in a model of stage IV breast cancer

Treatment of stage IV metastatic breast cancer patients is limited to palliative options and represents an unmet clinical need. Here, we demonstrate that pharmacological inhibition of miRNA-10b - a master regulator of metastatic cell viability – leads to elimination of distant metastases in a mouse...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Yoo, Byunghee, Kavishwar, Amol, Wang, Ping, Ross, Alana, Pantazopoulos, Pamela, Dudley, Michael, Moore, Anna, Medarova, Zdravka
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359550/
https://ncbi.nlm.nih.gov/pubmed/28322342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45060
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