Lenalidomide Enhances Immune Checkpoint Blockade Induced Immune Response in Multiple Myeloma

PURPOSE: PD1/PD-L1 signaling promotes tumor growth while inhibiting effector cell-mediated anti-tumor immune responses. Here we assessed the impact of single and dual blockade of PD1/PD-L1, alone or in combination with lenalidomide, on accessory and immune cell function as well as multiple myeloma (...

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Publicado no:Clin Cancer Res
Main Authors: Görgün, Güllü Topal, Samur, Mehmet K., Cowens, Kristen B., Paula, Steven, Bianchi, Giada, Anderson, Julie E., White, Randie E., Singh, Ahaana, Ohguchi, Hiroto, Suzuki, Rikio, Kikuchi, Shohei, Harada, Takeshi, Hideshima, Teru, Tai, Yu-Tzu, Laubach, Jacob P., Raje, Noopur, Magrangeas, Florence, Minvielle, Stephane, Avet-Loiseau, Herve, Munshi, Nikhil C., Dorfman, David M., Richardson, Paul G., Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609232/
https://ncbi.nlm.nih.gov/pubmed/25979485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0200
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