Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.

We have analyzed somatic hypermutation in mice carrying an immunoglobulin kappa transgene in order to discriminate mutations that reflect the intrinsic specificity of the hypermutation mechanism from those highlighted by antigenic selection. We have immunized animals with three different immunogens....

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Betz, A G, Rada, C, Pannell, R, Milstein, C, Neuberger, M S
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1993
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46091/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8460148/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.6.2385
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