Caricamento...
Loss of long-chain acyl-CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation
Because hearts with a temporally induced knockout of acyl-CoA synthetase 1 (Acsl1(T−/−)) are virtually unable to oxidize fatty acids, glucose use increases 8-fold to compensate. This metabolic switch activates mechanistic target of rapamycin complex 1 (mTORC1), which initiates growth by increasing p...
Salvato in:
| Pubblicato in: | FASEB J |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Federation of American Societies for Experimental Biology
2015
|
| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4608904/ https://ncbi.nlm.nih.gov/pubmed/26220174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-272732 |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !
|