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Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function

Long-chain acyl-CoA synthetase 1 (ACSL1) contributes more than 90% of total cardiac ACSL activity, but its role in phospholipid synthesis has not been determined. Mice with an inducible knockout of ACSL1 (Acsl1(T−/−)) have impaired cardiac fatty acid oxidation and rely on glucose for ATP production....

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Grevengoed, Trisha J., Martin, Sarah A., Katunga, Lalage, Cooper, Daniel E., Anderson, Ethan J., Murphy, Robert C., Coleman, Rosalind A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513998/
https://ncbi.nlm.nih.gov/pubmed/26136511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M059717
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