Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death

Plasma membrane integrity is essential for cell life. Any major break on it immediately induces the death of the affected cell. Different molecules were described as disrupting this cell structure and thus showing antitumor activity. We have previously defined that elisidepsin (Irvalec(®), PM02734)...

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Udgivet i:PLoS One
Main Authors: Molina-Guijarro, José Manuel, García, Carolina, Macías, Álvaro, García-Fernández, Luis Francisco, Moreno, Cristina, Reyes, Fernando, Martínez-Leal, Juan Fernando, Fernández, Rogelio, Martínez, Valentín, Valenzuela, Carmen, Lillo, M. Pilar, Galmarini, Carlos M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608773/
https://ncbi.nlm.nih.gov/pubmed/26474061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140782
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