Irvalec Inserts into the Plasma Membrane Causing Rapid Loss of Integrity and Necrotic Cell Death in Tumor Cells

Irvalec is a marine-derived antitumor agent currently undergoing phase II clinical trials. In vitro, Irvalec induces a rapid loss of membrane integrity in tumor cells, accompanied of a significant Ca(2+) influx, perturbations of membrane conductivity, severe swelling and the formation of giant membr...

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Detalhes bibliográficos
Main Authors: Molina-Guijarro, José M., Macías, Álvaro, García, Carolina, Muñoz, Eva, García-Fernández, Luis F., David, Miren, Núñez, Lucía, Martínez-Leal, Juan F., Moneo, Victoria, Cuevas, Carmen, Lillo, M. Pilar, Villalobos Jorge, Carlos, Valenzuela, Carmen, Galmarini, Carlos M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083409/
https://ncbi.nlm.nih.gov/pubmed/21556352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019042
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