A Phenomic Scan of the Norfolk Island Genetic Isolate Identifies a Major Pleiotropic Effect Locus Associated with Metabolic and Renal Disorder Markers

Multiphenotype genome-wide association studies (GWAS) may reveal pleiotropic genes, which would remain undetected using single phenotype analyses. Analysis of large pedigrees offers the added advantage of more accurately assessing trait heritability, which can help prioritise genetically influenced...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:PLoS Genet
Main Authors: Benton, Miles C., Lea, Rodney A., Macartney-Coxson, Donia, Hanna, Michelle, Eccles, David A., Carless, Melanie A., Chambers, Geoffrey K., Bellis, Claire, Goring, Harald H., Curran, Joanne E., Harper, Jacquie L., Gibson, Gregory, Blangero, John, Griffiths, Lyn R.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2015
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608754/
https://ncbi.nlm.nih.gov/pubmed/26474483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005593
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