A Phenomic Scan of the Norfolk Island Genetic Isolate Identifies a Major Pleiotropic Effect Locus Associated with Metabolic and Renal Disorder Markers

Multiphenotype genome-wide association studies (GWAS) may reveal pleiotropic genes, which would remain undetected using single phenotype analyses. Analysis of large pedigrees offers the added advantage of more accurately assessing trait heritability, which can help prioritise genetically influenced...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Benton, Miles C., Lea, Rodney A., Macartney-Coxson, Donia, Hanna, Michelle, Eccles, David A., Carless, Melanie A., Chambers, Geoffrey K., Bellis, Claire, Goring, Harald H., Curran, Joanne E., Harper, Jacquie L., Gibson, Gregory, Blangero, John, Griffiths, Lyn R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608754/
https://ncbi.nlm.nih.gov/pubmed/26474483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005593
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