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The Genotype of the Donor for the (GT)(n) Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Does Not Affect the GVL Effect after Myeloablative HLA-Identical Allogeneic Stem Cell Transplantation
The FOXP3 gene encodes for a protein (Foxp3) involved in the development and functional activity of regulatory T cells (CD4+/CD25+/Foxp3+), which exert regulatory and suppressive roles over the immune system. After allogeneic stem cell transplantation, regulatory T cells are known to mitigate graft...
Zapisane w:
Wydane w: | PLoS One |
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Główni autorzy: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Artigo |
Język: | Inglês |
Wydane: |
Public Library of Science
2015
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4608671/ https://ncbi.nlm.nih.gov/pubmed/26473355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140454 |
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