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X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine
Most antidepressants elicit their therapeutic benefits through selective blockade of Na(+−)Cl(−) - coupled neurotransmitters transporters. Here we report x-ray structures of the Drosophila melanogaster dopamine transporter in complexes with the polycyclic antidepressants nisoxetine or reboxetine. Th...
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| Publicado no: | Nat Struct Mol Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4608549/ https://ncbi.nlm.nih.gov/pubmed/25961798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3029 |
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