Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology

The multigram-scale synthesis of a sulfation-site programmed heparin-like dodecasaccharide is described. Evaluation alongside dodecasaccharides lacking this single glucosamine O6-sulfation, or having per-O6-sulfation, shows that site-specific modification of the terminal glucosamine dramatically int...

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Bibliografiske detaljer
Udgivet i:Chem Commun (Camb)
Main Authors: Jayson, Gordon C., Hansen, Steen U., Miller, Gavin J., Cole, Claire L., Rushton, Graham, Avizienyte, Egle, Gardiner, John M.
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2015
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608306/
https://ncbi.nlm.nih.gov/pubmed/26234943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cc05222j
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