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Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER

BACKGROUND: Estrogen (17β-estradiol) promotes the survival and proliferation of breast cancer cells and its receptors represent important therapeutic targets. The cellular actions of estrogen are mediated by the nuclear estrogen receptors ERα and ERβ as well as the 7-transmembrane spanning G protein...

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Publicat a:BMC Cancer
Autors principals: Zekas, Erin, Prossnitz, Eric R.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608161/
https://ncbi.nlm.nih.gov/pubmed/26470790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1699-6
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