Structure-activity Relationship Studies of QS11, a Small Molecule Wnt Synergistic Agonist

Both the Wnt/β-catenin signaling pathway and small GTPases of the ADP-ribosylation factors (ARF) family play important roles in regulating cell development, homeostasis and fate. The previous report of QS11, a small molecule Wnt synergist that binds to ARF GTPase-activating protein 1 (ARFGAP1), sugg...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioorg Med Chem Lett
Main Authors: Singh, Manish K., Gao, Huanyao, Sun, Wei, Song, Zhiquan, Schmalzigaug, Robert, Premontand, Richard T., Zhang, Qisheng
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607626/
https://ncbi.nlm.nih.gov/pubmed/26152429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.06.062
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