Serum Amyloid A Stimulates PKR Expression and HMGB1 Release Possibly through TLR4/RAGE Receptors

Serum amyloid A (SAA) proteins are known to be surrogate markers of sepsis, but their pathogenic roles remain poorly elucidated. Here we provide evidence to support a possible role of SAA as a pathogenic mediator of lethal sepsis. In a subset of septic patients for which serum high mobility group bo...

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Vydáno v:Mol Med
Hlavní autoři: Li, Wei, Zhu, Shu, Li, Jianhua, D’Amore, Jason, D’Angelo, John, Yang, Huan, Wang, Ping, Tracey, Kevin J, Wang, Haichao
Médium: Artigo
Jazyk:Inglês
Vydáno: ScholarOne 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607615/
https://ncbi.nlm.nih.gov/pubmed/26052716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2015.00109
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