Mixed Up Minor Groove Binders: Convincing A•T Specific Compounds to Recognize a G•C Base Pair

DNA minor-groove-binding compounds have limited biological applications, in part due to problems with sequence specificity that cause off-target effects. A model to enhance specificity has been developed with the goal of preparing compounds that bind to two AT sites separated by G•C base pairs. Comp...

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Gepubliceerd in:Bioorg Med Chem Lett
Hoofdauteurs: Paul, Ananya, Nanjunda, Rupesh, Kumar, Arvind, Laughlin, Sarah, Nhili, Raja, Depauw, Sabine, Deuser, Shelby Sheldon, Chai, Yun, Chaudhary, Arpana S., David-Cordonnier, Marie-Hélène, Boykin, David W., Wilson, W. David
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607563/
https://ncbi.nlm.nih.gov/pubmed/26051649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.05.005
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