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HMGB1 induction of clusterin creates a chemoresistant niche in human prostate tumor cells

Development of chemoresistance, especially to docetaxel (DTX), is the primary barrier to the cure of castration-resistant prostate cancer but its mechanism is obscure. Here, we report a seminal crosstalk between dying and residual live tumor cells during treatment with DTX that can result in outgrow...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Zhou, Junmin, Chen, Xianghong, Gilvary, Danielle L., Tejera, Melba M., Eksioglu, Erika A., Wei, Sheng, Djeu, Julie Y.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4606829/
https://ncbi.nlm.nih.gov/pubmed/26469759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15085
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