Inhibitory Effect of the Noncamptothecin Topoisomerase I Inhibitor LMP-400 on Female Mice Models and Human Pheochromocytoma Cells

Metastatic pheochromocytoma continues to be an incurable disease, and treatment with conventional cytotoxic chemotherapy offers limited efficacy. In the present study, we evaluated a novel topoisomerase I inhibitor, LMP-400, as a potential treatment for this devastating disease. We found a high expr...

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Publicado en:Endocrinology
Autores principales: Schovanek, Jan, Bullova, Petra, Tayem, Yasin, Giubellino, Alessio, Wesley, Robert, Lendvai, Nikoletta, Nölting, Svenja, Kopacek, Juraj, Frysak, Zdenek, Pommier, Yves, Kummar, Shivaani, Pacak, Karel
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2015
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4606751/
https://ncbi.nlm.nih.gov/pubmed/26267380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1476
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