Inhibitory Effect of the Noncamptothecin Topoisomerase I Inhibitor LMP-400 on Female Mice Models and Human Pheochromocytoma Cells

Metastatic pheochromocytoma continues to be an incurable disease, and treatment with conventional cytotoxic chemotherapy offers limited efficacy. In the present study, we evaluated a novel topoisomerase I inhibitor, LMP-400, as a potential treatment for this devastating disease. We found a high expr...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Schovanek, Jan, Bullova, Petra, Tayem, Yasin, Giubellino, Alessio, Wesley, Robert, Lendvai, Nikoletta, Nölting, Svenja, Kopacek, Juraj, Frysak, Zdenek, Pommier, Yves, Kummar, Shivaani, Pacak, Karel
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4606751/
https://ncbi.nlm.nih.gov/pubmed/26267380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1476
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