Tetrathiomolybdate inhibits mitochondrial complex IV and mediates degradation of hypoxia-inducible factor-1α in cancer cells

Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that triggers adaptive responses upon low oxygen conditions and plays a crucial role in cancer metabolism and therapy resistance. Tetrathiomolybdate (TM), a therapy option for copper overload disorder, has also been shown to be capable o...

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Vydáno v:Sci Rep
Hlavní autoři: Kwang Kim, Kyu, Abelman, Sarah, Yano, Naohiro, Ribeiro, Jennifer R., Singh, Rakesh K., Tipping, Marla, Moore, Richard G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4606568/
https://ncbi.nlm.nih.gov/pubmed/26469226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14296
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