Selective Histone Deacetylase 6 inhibition Prolongs Survival in a Lethal Two-hit Model

INTRODUCTION: Hemorrhagic shock (HS) followed by a subsequent insult (“second hit”) often initiates an exaggerated systemic inflammatory response and multiple organ failure. We have previously demonstrated that valproic acid, a pan histone deacetylase (HDAC) inhibitor, could improve survival in a ro...

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Vydáno v:J Surg Res
Hlavní autoři: Cheng, Xin, Liu, Zhengcai, Liu, Baoling, Zhao, Ting, Li, Yongqing, Alam, Hasan B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4606460/
https://ncbi.nlm.nih.gov/pubmed/25837686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2015.02.070
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