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Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRL(lpr) Mice
The role of IL-18 in the pathogenesis of systemic lupus erythematosus is still not definitively solved. In this study, we generated MRL(lpr) mice, which develop a disease resembling systemic lupus erythematosus, genetically devoid of IL-18 expression. These mice in comparison to IL-18-competent MRL(...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4605611/ https://ncbi.nlm.nih.gov/pubmed/26465326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140173 |
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