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Tricyclic antidepressants and mecamylamine bind to different sites in the human α4β2 nicotinic receptor ion channel
The interaction of tricyclic antidepressants with the human (h) α4β2 nicotinic acetylcholine receptor in different conformational states was compared with that for the noncompetitive antagonist mecamylamine by using functional and structural approaches. The results established that: (a) [(3)H]imipra...
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| Veröffentlicht in: | Int J Biochem Cell Biol |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4605392/ https://ncbi.nlm.nih.gov/pubmed/20223294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2010.03.002 |
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