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Tricyclic antidepressants and mecamylamine bind to different sites in the human α4β2 nicotinic receptor ion channel

The interaction of tricyclic antidepressants with the human (h) α4β2 nicotinic acetylcholine receptor in different conformational states was compared with that for the noncompetitive antagonist mecamylamine by using functional and structural approaches. The results established that: (a) [(3)H]imipra...

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Bibliografiska uppgifter
I publikationen:Int J Biochem Cell Biol
Huvudupphovsmän: Arias, Hugo R., Rosenberg, Avraham, Targowska-Duda, Katarzyna M., Feuerbach, Dominik, Jozwiak, Krzysztof, Moaddel, Ruin, Wainer, Irving W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605392/
https://ncbi.nlm.nih.gov/pubmed/20223294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2010.03.002
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