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Tricyclic antidepressants and mecamylamine bind to different sites in the human α4β2 nicotinic receptor ion channel
The interaction of tricyclic antidepressants with the human (h) α4β2 nicotinic acetylcholine receptor in different conformational states was compared with that for the noncompetitive antagonist mecamylamine by using functional and structural approaches. The results established that: (a) [(3)H]imipra...
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| Publicado no: | Int J Biochem Cell Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4605392/ https://ncbi.nlm.nih.gov/pubmed/20223294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2010.03.002 |
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