Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage

CRISPR-associated endonuclease Cas9 cuts DNA at variable target sites designated by a Cas9-bound RNA molecule. Cas9's ability to be directed by single ‘guide RNA’ molecules to target nearly any sequence has been recently exploited for a number of emerging biological and medical applications. Th...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Josephs, Eric A., Kocak, D. Dewran, Fitzgibbon, Christopher J., McMenemy, Joshua, Gersbach, Charles A., Marszalek, Piotr E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605321/
https://ncbi.nlm.nih.gov/pubmed/26384421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv892
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