A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2′-dC upon inhibition of ribonucleotide reductase

BACKGROUND: DNA methylation is important for the maintenance of the silent state of genes on the inactive X chromosome (Xi). Here, we screened for siRNAs and chemicals that reactivate an Xi-linked reporter in the presence of 5-aza-2′-deoxycytidine (5-aza-2′-dC), an inhibitor of DNA methyltransferase...

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Veröffentlicht in:Epigenetics Chromatin
Hauptverfasser: Minkovsky, Alissa, Sahakyan, Anna, Bonora, Giancarlo, Damoiseaux, Robert, Dimitrova, Elizabeth, Rubbi, Liudmilla, Pellegrini, Matteo, Radu, Caius G., Plath, Kathrin
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604769/
https://ncbi.nlm.nih.gov/pubmed/26468331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-015-0034-4
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