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Combinations of Alkaloids Affecting Different Molecular Targets with the Saponin Digitonin Can Synergistically Enhance Trypanocidal Activity against Trypanosoma brucei brucei

The flagellate Trypanosoma brucei causes sleeping sickness in humans and nagana in animals. Only a few drugs are registered to treat trypanosomiasis, but those drugs show severe side effects. Also, because some pathogen strains have become resistant, new strategies are urgently needed to combat this...

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Foilsithe in:Antimicrob Agents Chemother
Main Authors: Krstin, Sonja, Peixoto, Herbenya Silva, Wink, Michael
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604350/
https://ncbi.nlm.nih.gov/pubmed/26349826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01315-15
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