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Combinations of Alkaloids Affecting Different Molecular Targets with the Saponin Digitonin Can Synergistically Enhance Trypanocidal Activity against Trypanosoma brucei brucei

The flagellate Trypanosoma brucei causes sleeping sickness in humans and nagana in animals. Only a few drugs are registered to treat trypanosomiasis, but those drugs show severe side effects. Also, because some pathogen strains have become resistant, new strategies are urgently needed to combat this...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Krstin, Sonja, Peixoto, Herbenya Silva, Wink, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604350/
https://ncbi.nlm.nih.gov/pubmed/26349826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01315-15
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