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Interaction of Monobenzamidine-Linked Trypanocides with the Trypanosoma brucei P2 Aminopurine Transporter

Single benzamidine group-carrying compounds were shown to interact with the Trypanosoma brucei P2 aminopurine transporter. Replacement of the amidine with a guanidine group decreased affinity. Trypanocidal activity was evident, but compounds were equally toxic against trypanosomes lacking the P2 tra...

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Detalles Bibliográficos
Main Authors: Stewart, Mhairi L., Boussard, Cyrille, Brun, Reto, Gilbert, Ian H., Barrett, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315980/
https://ncbi.nlm.nih.gov/pubmed/16304196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.12.5169-5171.2005
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