Direct determination of protonation states and visualization of hydrogen bonding in a glycoside hydrolase with neutron crystallography

Glycoside hydrolase (GH) enzymes apply acid/base chemistry to catalyze the decomposition of complex carbohydrates. These ubiquitous enzymes accept protons from solvent and donate them to substrates at close to neutral pH by modulating the pK(a) values of key side chains during catalysis. However, it...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Wan, Qun, Parks, Jerry M., Hanson, B. Leif, Fisher, Suzanne Zoe, Ostermann, Andreas, Schrader, Tobias E., Graham, David E., Coates, Leighton, Langan, Paul, Kovalevsky, Andrey
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4603456/
https://ncbi.nlm.nih.gov/pubmed/26392527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504986112
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