Direct determination of protonation states and visualization of hydrogen bonding in a glycoside hydrolase with neutron crystallography

Glycoside hydrolase (GH) enzymes apply acid/base chemistry to catalyze the decomposition of complex carbohydrates. These ubiquitous enzymes accept protons from solvent and donate them to substrates at close to neutral pH by modulating the pK(a) values of key side chains during catalysis. However, it...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Wan, Qun, Parks, Jerry M., Hanson, B. Leif, Fisher, Suzanne Zoe, Ostermann, Andreas, Schrader, Tobias E., Graham, David E., Coates, Leighton, Langan, Paul, Kovalevsky, Andrey
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4603456/
https://ncbi.nlm.nih.gov/pubmed/26392527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504986112
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